Cornerbacks Chris Houston (ankle) and Bill Bentley (concussion) were both deactivated and won't be in uniform. The Lions announced Drayton Florence and Jacob Lacey as their replacements, and it's expected that Kevin Barnes and Jonte Green will be on the field when the Lions need extra defensive backs.
On the other hand, Lions receiver Ryan Broyles will be in uniform after being deactivated for last week's game against the St. Louis Rams. As we discussed last week, the Lions had significant success against the 49ers last season on passes between the numbers. Broyles thrives on inside passes and could be a valuable weapon against the 49ers' defense.
Finally, defensive tackle Corey Williams is in the starting lineup even though he missed practice all week because of a knee injury.