Five nuggets of knowledge about Week 6:
All about third down. The San Francisco 49ers offense took considerable criticism after converting just once on 13 third-down plays against the New York Giants in the NFC Championship Game. The 49ers defense deserves some third-down scrutiny heading into the rematch at Candlestick Park. The 2011 49ers held the Giants to 4.6 yards per play with no touchdowns on first and second downs during the teams' regular-season game last season. Everything changed on third down. The Giants averaged 8.8 yards per third-down play against the 49ers. They gained 127 yards and scored two touchdowns on 10 third-down pass attempts against the 49ers' nickel defense, without taking a sack. The 49ers were much better getting third-down pressure in the playoff rematch, but the Giants still averaged 7.2 yards per pass attempt with seven first downs on third-down plays against the 49ers' nickel defense.
Letting Welker catch it. The Seahawks' matchup against Patriots receiver Wes Welker will be a difficult one. The key, coach Pete Carroll has said, will be for Seattle to limit the damage once Welker inevitably gets the ball in his hands. This is probably an underrated aspect of the Seahawks' league-leading defense. Seattle is allowing 4.09 yards after the catch per reception. That ranks second in the NFL behind Minnesota (3.9) and just ahead of Green Bay (4.12). The figure for Seattle was 4.9 last season and 5.8 in 2010. Welker averages 6.4 YAC/reception, a significant figure given how many passes he catches (NFL-high 30 over the last three games, with 6.5 YAC/reception on those catches). The Seahawks have allowed 3.6 YAC/reception against wide receivers lined up in the slot, where Welker lines up most of the time. That figure ranks 12th in the NFL (the range is 1.9 to 8.1, with 4.5 as average).
Behold the Hyphen. LaRod Stephens-Howling's return from a hip injury comes at the right time for Arizona. Fellow running backs Beanie Wells and Ryan Williams are out. Stephens-Howling has been a utility player for Arizona, not an every-down back, because he lacks the size needed to run on early downs, week after week. Desperate times call for desperate measures, however, and that could mean leaning on Stephens-Howling a little more regularly. The 5-foot-7, 180-pounder set career highs with 21 carries and 92 yards during a victory over Seattle in Week 17 last season. Four of his longest runs that day -- 39, 8, 8 and 7 yards -- came on first down with no more than two wide receivers on the field. Can Stephens-Howling, William Powell and Alfonso Smith help the NFL's worst rushing offense (2.7 yards per carry) exploit Buffalo's league-worst rushing defense (5.7 yards per carry allowed)?
First-and-Long. The Miami Dolphins made left tackle Jake Long the first player chosen in the 2008 NFL draft. The St. Louis Rams took defensive end Chris Long with the second pick. Both players will be on the field at the same time when the Rams visit the Dolphins, but they'll be matching up against younger players. Jake Long faces 2011 Rams first-rounder Robert Quinn, who is coming off a three-sack game and has already exceeded his total for last season. Chris Long faces Dolphins right tackle Jonathan Martin, a second-round choice this year. Both Longs should like their chances in these matchups. If Quinn's speed can factor in the pass rush, perhaps St. Louis can force Dolphins quarterback Ryan Tannehill into mistakes.
Readying the stat sheet. Last week, the 49ers had a 300-yard passer, 100-yard rusher and two 100-yard receivers for the first time since 1961. Meanwhile, the Giants became the first NFL team since 1960 to have one player rush for at least 200 yards (Ahmad Bradshaw) while another player caught three touchdown passes (Victor Cruz). There is more. The 49ers have won each of their last two games by 30-plus points, the first time since 1961 they've accomplished the feat (they have never done it three games in a row). The Giants have set a franchise record for any four-game stretch with 1,877 yards against Tampa Bay, Carolina, Philadelphia and Cleveland.
Note: ESPN Stats & Information contributed to this item.