What it means: The Ravens' title defense -- as well as life without Ray Lewis and Ed Reed -- opened with a dud. This is the first season-opening loss for coach John Harbaugh and quarterback Joe Flacco in their six years together, and it wasn't even close. An interception by Flacco in his own territory, a blocked punt and a drop near the goal line all led to the worst loss by a defending Super Bowl champion in a season opener, according to the Elias Sports Bureau. The 49 points are the most allowed by the Ravens in their history.
Stock watch: Falling -- Ravens secondary. The Ravens gave up an NFL-record-tying seven touchdown passes, and everyone took turns getting roughed up. Safety Michael Huff couldn't keep up with tight end Julius Thomas (two touchdowns), cornerback Corey Graham struggled covering Wes Welker (two touchdowns) and cornerback Jimmy Smith watched a good game turn bad when he was beaten by Andre Caldwell (one touchdown). The Ravens allowed Peyton Manning to throw three touchdowns in a disastrous third quarter, which turned Baltimore's 17-14 lead into a 35-17 deficit.
Why not challenge?: With the Ravens ahead 17-14 early in the third quarter, Welker trapped a ball that was ruled a completion, which converted a third down. If Harbaugh had challenged, the drive would've ended. Instead, Manning rushed to the line to snap the ball, and three plays later, Caldwell scored a 28-yard touchdown. The Broncos took a lead they would never relinquish.
Too many drops: The loss of tight end Dennis Pitta (hip injury) was felt right away. Dallas Clark and Ed Dickson dropped at least five passes. The devastating one was Clark failing to hold onto a third-down pass inside the 5-yard line. The Ravens had to settle for a field goal and a 17-14 lead at halftime.
Self-inflicted: Two Ravens starters were hurt in the second quarter by their own teammates. On a punt return, Jacoby Jones was leveled by rookie Brynden Trawick and suffered a sprained knee. Then, on Ray Rice's one-yard touchdown run, right tackle Michael Oher sprained his ankle when guard Marshal Yanda rolled into him. Two rookies, wide receiver Marlon Brown and offensive tackle Rick Wagner, replaced the veterans in the starting lineup.
What's next: The Ravens (0-1) get nine days before playing the Cleveland Browns at Baltimore's M&T Bank Stadium on Sept. 15. Baltimore has a 10-game winning streak over Cleveland.