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Arizona Cardinals (2-1) at New York Jets (1-2), 1 p.m. ET
The Jets need a victory amid myriad concerns arising from Monday night's loss to the San Diego Chargers.
The Jets are coming off a wobbly all-around game. They opened up their offense for Brett Favre, who nearly threw what seemed like 13 interceptions and injured his ankle. The defense allowed 48 points and yielded a slew of critical plays, especially after nose tackle Kris Jenkins left with a back injury. Jets coach Eric Mangini also had a rough game, making a controversial onside kick attempt that backfired in the second quarter.
That's a lot to recover from with a short week of preparation. Thankfully for Jets fans, Favre and Jenkins are expected to play, and their opponents are coming off a defeat of their own.
Arizona presents a potentially high-flying attack, with Kurt Warner flinging the ball to powerful receivers Larry Fitzgerald and Anquan Boldin. New York's secondary absolutely will have a busy day and probably will determine the outcome.
Buffalo Bills (3-0) at St. Louis Rams (0-3), 4:05 p.m. ET
Good things happen to the Bills when they win their first three games. Over the past quarter-century it has happened four times. They reached the AFC title game each time and advanced to the Super Bowl twice.
The Rams are the perfect foil -- OK, the perfect NFC foil -- to help the Bills go 4-0 for the first time since 1992, their third Super Bowl season, and set them up for a possible 5-0 record (if they can beat the Cardinals on the road Oct. 5) heading into their bye week.
The Rams rank second-from-the-bottom in total offense and dead last in total defense. They're starting a quarterback known for throwing interceptions and getting concussed. The Bills, meanwhile, have one of the league's nastiest defenses.
Buffalo's defense ranks sixth in points allowed, fifth in yards allowed and first in third-down efficiency. The Bills might chase Green down I-70 and all the way back to the Chiefs.
Trent Edwards has been surgically efficient in the fourth quarter, and running back Marshawn Lynch has been strong like bull, but the Bills will give the Rams hope if their offense starts as slowly as it did last Sunday against the Oakland Raiders.