Big-play potential: The Colts' game in Detroit features the NFL’s top two players in receiving yards. The Lions' Calvin Johnson (1,257) and Indianapolis’ Reggie Wayne (1,105) are the primary guys in their respective offenses. Since Johnson entered the league in 2007, they are also both in the top three in the NFL in receiving yards, with Wayne second and Johnson third behind No. 1 Roddy White. We can expect both receivers to get chances downfield. Per ESPN Stats & Info, Andrew Luck has thrown 125 passes this season that have traveled at least 15 yards downfield, the most in the league. Matthew Stafford is second with 106 such attempts. Pass defense will be an issue on both sides at Ford Field. Neither team features cornerbacks of the caliber of those receivers, which means quality pass-rushing will be extra important.
Houston defensive coordinator Wade Phillips will match wits against Tennessee's Dowell Loggains, who will be calling plays for the first time.
Rematch: The Texans defeated the Titans 38-14 in Week 4. Houston is seeking a season sweep of the Titans for the second time in its history and first time since 2004. Jake Locker suffered a shoulder injury early in that game when an unblocked, blitzing Glover Quin drove Locker's nonthrowing shoulder into the ground. The big story is the coordinator matchup when the Titans have the ball. Texans defensive coordinator Wade Phillips is one of the best in the business, and he will be trying to outfox Dowell Loggains, the Titans' new offensive coordinator who will be calling his first game. The Texans have allowed more than 30 points in back-to-back games after allowing that many just once in their first nine games.
Streaking with Henne? The Jaguars seek back-to-back wins for the first time since Weeks 13 and 14 of the 2010 season. In the past two games with Chad Henne doing most of the quarterbacking, the Jaguars have jumped from 14.1 points per game to 30.5, and from 263.6 yards per game to 389.5. Rookie receiver Justin Blackmon has been a big part of that, with more receiving yards in Weeks 11 and 12 (298) than he had in the first 10 games (250). But Blackmon and the team’s other top receiver, Cecil Shorts, didn’t practice Thursday because of leg injuries; their status for Sunday’s game in Buffalo is in doubt.
Heading for 1,000:Chris Johnson needs 58 rushing yards for his fifth consecutive 1,000-yard season to start his career. He would become the eighth player in NFL history to accomplish that, joining Curtis Martin and Barry Sanders (who did it for 10 consecutive seasons). The others were LaDainian Tomlinson (eight), Eric Dickerson (seven), Corey Dillon (six), Tony Dorsett and Eddie George (five each). In Johnson’s past six games, he has averaged 6.2 yards per carry and broken off 17 10-yard runs.
Also:Andre Johnson's 461 receiving yards in his past two games are the most in consecutive games in league history, per Elias Sports Bureau. With a 152-yard day, he would post the best three-game stretch ever, passing Charley Hennigan’s 612 yards for the Oilers in 1961. Johnson has been the Texans’ targeted receiver on 40.7 percent of the team’s play-action passes the past two games. Before that, he was the target on just 22.4 percent. … The Bills have been outscored by 72 points in the second half. … With a victory, Luck would become the first rookie quarterback selected No. 1 overall in the common draft era to win eight games. … The Titans rank 31st in points allowed (30.5 per game) and the Texans rank second in scoring (29.7). … Arian Foster has six consecutive 100-yard games on the road. He has scored a touchdown in every game but one.