Some notes and observations from the game:
Trent Edwards might have won the starting quarterback job with how he responded to one specific play. On a third-and-10 play in the first quarter, Colts defensive end Robert Mathis crushed Edwards while throwing. The hit knocked off Edwards' helmet and chipped a tooth. Two possessions and five plays later, Edwards hooked up with Lee Evans for a 70-yard touchdown bomb.
Bills coach Chan Gailey said of the sequence: "I never thought anything less would happen to be honest with you. All of our guys have moxie. You've got to have moxie to play quarterback in this league. I was impressed with that, really impressed with it. I asked after he got hit 'Are you OK?' He didn't even flinch. ... I think he's a tough guy."
Spiller's run snapped a string of 20 straight preseason possessions without a touchdown for the first-team offense. He's going to be fun to watch, one of those players who has a legitimate shot to score every time he touches the ball because he makes tacklers miss.
Backup quarterback Brian Brohm didn't get the most glorious opportunity to make an impression or gain ground on Edwards. Brohm could have gotten a series against the Colts' first-team defense, but Gailey sent Edwards out for a fifth possession with 11:49 left in the second quarter. Brohm entered the game with 6:05 left in the half.
Brohm's performance was OK against the Colts' backups. He threw a lot of high-percentage short stuff, completing 14 of 21 attempts for 125 yards with no touchdowns or no interceptions. He had a wonderful chance to throw for his first NFL touchdown right before halftime. The Bills had second-and-goal from the 5, but Brohm misfired on two passes. The Bills kicked a field goal.
Brohm set up the goal-to-go situation with a gorgeous pass and catch by Chad Jackson along the right sideline for a 26-yard gain.
Would have been nice to see Brohm air it out on third and long. In the third quarter, Brohm dumped off to Chad Simpson for 4 yards on a third-and-13 play. On a third-and-12 play two series later, the Bills ran.
Spiller was busy without Fred Jackson (broken hand) and Marshawn Lynch (sprained ankle). Spiller averaged only 14 carries his senior season at Clemson. He ran 10 times for 54 yards in a quarter and a half of work.
Spiller looked scintillating on his touchdown scamper, but his jitters and jukes didn't fool the Colts all the time. He averaged 2.6 yards on his other nine carries. He had runs that went for minus-6, minus-2, zero and 1 yards.
Overshadowed by Spiller was undrafted rookie running back Joique Bell, who ran 11 times for 80 yards and a touchdown. He's making a statement. Simpson, conversely, ran eight times for 8 yards.
The Bills' defense gave Peyton Manning some problems. He completed 8 of 15 passes for 91 yards and one touchdown with one interception. His 66.3 passer rating was less than half of Edwards'.
After an ugly opener against the Washington Redskins six days earlier, the defense rebounded with a great first series. Defensive lineman Marcus Stroud batted down Manning's first attempt. Cornerback Leodis McKelvin nearly intercepted a long ball to Reggie Wayne. Nose tackle Kyle Williams stuff Joseph Addai for a 3-yard loss on a screen pass.
Gailey said he was just wanted to give him more time in pass-rushing situations, but it's disconcerting to see last year's 11th overall draft choice, Aaron Maybin, on the field at the end of a preseason game.
Despite 35 points in the first quarter, the Rogers Centre was rather sterile again, just like the previous three Bills games played here. The announced crowd was 39,853 fans.
The crowd, however, got interesting in the final minutes. Perhaps the best play of the night: A Rogers Centre security guard chasing down a fan who sprinted onto the field with 1:55 left in the game. The fan had about a 20-yard head start, but the guard caught up to him and slammed his head to the turf. As the guard walked back past the Colts sideline, Wayne went out of his way to give him a high-five.