But outside linebacker Melvin Ingram says he doesn't get any added motivation from playing his AFC West division rivals.
"We're trying to destroy everybody," Ingram said. "That's our main goal, is to beat everybody. So everybody is a rivalry to us."
And why is that?
"I feel like to be a winner and a champion you've got to want to destroy everybody that's in your way," Ingram said. "Because if you've got that mentality that somebody can destroy you, then you really aren't striving toward success."
That said, center Nick Hardwick, who's been with the Chargers for 10 seasons, said there's an increased focus when his team faces the Raiders.
"We're happy to be playing the Oakland Raiders, absolutely," Hardwick said. "There's a good amount of energy. But at the end of the day, we just have to come in, know our assignments and execute with an attitude."
The Chargers remain healthy in terms of injuries. Hardwick and receiver Eddie Royal did not practice on Wednesday. Hardwick had a rest day, and Royal continues to miss practice but play in games while dealing with a toe issue.
Running back Ryan Mathews was limited with a foot injury.
San Diego also added cornerback Brandon Jones to the team's practice squad. At 6-foot-1, 190 pounds, Jones initially signed with New England as an undrafted rookie in May after playing at Rutgers.
Released by the Patriots at the end of training camp, Jones spent three weeks on the New York Giants' practice squad, and one week on Pittsburgh's practice squad.