But if he doesn’t have a setback Willis could play. He missed last week’s game at St. Louis with a groin injury that knocked him out of the third quarter of a Week 3 loss to the Colts. Thursday, San Francisco defensive coordinator Vic Fangio said Willis is more than “50-50” to play.
Willis will likely be a game-time decision. Michael Wilhoite will take his place against Houston if Willis can’t play Sunday.
Meanwhile, the NFL confirmed a Bay Area News Group reported 49ers defensive lineman Justin Smith was fined $7,875 for a facemask penalty against the Rams. Safety Donte Whitner was previously fined $21,000 for a hit in the game. Whitner is appealing the fine.