Inside linebacker Patrick Willis is inactive and will miss his second straight game with a groin injury he suffered in Week 3 in a loss to the Indianapolis Colts. Willis worked out on the field Sunday and met with team physicians. Clearly, the team felt it was too risky for Willis to play. Michael Wilhoite will start for Willis as he did in week 4 against the Rams.
Of course, the 49ers are also playing without pass-rusher Aldon Smith. He went into an undisclosed alcohol treatment center 13 days ago.