Frank Gore is 38 yards away from his eighth 1,000-yard rushing season in his 10th year as an NFL running back.
Anquan Boldin needs 19 yards for his seventh 1,000-yard receiving season in his 12th year, just his second such campaign since 2009.
"For us to be successful, those guys have to do well," 49ers offensive coordinator Greg Roman said Tuesday. "So, they should really be part and parcel with one another. I don’t think you want to go into the game saying, 'Hey our goal today, guys, is to get Frank 1,000 and Boldin 1,000.'
"That is definitely part of the equation if we can handle our business."
Gore is coming off a season-high 158 yards rushing against the San Diego Chargers, six days after suffering a concussion against the Seattle Seahawks. He was averaging a career-low 3.9 yards per carry entering last weekend, but is now averaging 4.2.
"That’s pretty remarkable as far as his toughness," Roman said. "Made a couple great runs. Broke a bunch of tackles. The downfield blocking was outstanding, but he broke a bunch of tackles. He was definitely a workhorse."
Gore is in the final year of his contract, and it is widely believed he will leave the 49ers after this season. He told the Associated Press he wanted to return to Santa Clara.
"Hopefully I’ll be back," Gore said. "The organization, they love me and they respect me. I want to be back, yeah, hey, I was raised here. I don’t know nothing else."
And general manager Trent Baalke echoed those statements. Kinda.
"He understands what he means to this organization," Baalke told CSNBayArea.com. "He would certainly like to be back, and we would certainly like to have him back. Now, whether we can make that a reality or not, time will tell."
Boldin, meanwhile, had 1,179 receiving yards last season, on 85 catches, his first 1,000-yard receiving season since 2009. He is leading the 49ers in receptions (81), receiving yards (981) and receiving TDs (four) in 15 games this season.