Simon (5-2) got the win, allowing two unearned runs on four hits and a walk in seven innings. Simon, who struck out five, used his slow curve effectively, throwing it so softly once that it didn't register on the radar gun.
Collin McHugh (5-2) lost for just the second time in his last 14 decisions, giving up three runs on nine hits and a walk in seven innings. McHugh's two losses have been in his last three starts after he had gone unbeaten in 16 outings dating back to last August.
A rare lapse by Detroit's infield defense gave the Astros two runs in the top of the third. With two out, Ian Kinsler misplayed a routine grounder, allowing Jason Castro to score, and George Springer followed with a 420-foot RBI double over centerfielder Anthony Gose's head.
The Tigers, though, came back with three in their half of the inning. After Jose Iglesias and Gose singled to start the inning, McHugh retired Kinsler and Miguel Cabrera. Martinez hit McHugh's next pitch 350 feet foul down the left-field line, then hit an 0-1 fastball into the right-field stands for a three-run homer.
Detroit made the game safe with three runs in the eighth. Cabrera singled, took third on Luis Valbuena's error and scored on Rajai Davis's two-out infield single. Davis then stole second before McCann's two-run single.
Astros: RHP Josh Fields, who left Thursday's game after being hit in the right knee by a line drive, is expected to miss a day or two. "It's not comfortable," he said. "It's pretty stiff. I don't know. I guess we'll see what happens."
Tigers: RHP Justin Verlander, who has not pitched this season due to a triceps strain, is scheduled to throw a simulated game on Tuesday. If that goes well, the team will decide if he is ready for a minor-league rehab stint. ... RHP Bruce Rondon threw 22 pitches in a rehab outing for Triple-A Toledo, and experienced no discomfort. Rondon, who missed all of last season after Tommy John surgery, has been battling a bicep injury since spring training.
The Tigers and Astros play the third game of the weekend series Saturday afternoon, with Kyle Lobstein (3-4, 4.29) facing Lance McCullers Jr. (0-0, 1.93). McCullers, who will be making his second career start, will face the Tigers 25 years after his father joined Detroit in a trade with the Yankees on June 4, 1990.