Buffalo's pass rush: The Bucs are coming off a loss to Carolina in which they gave up five sacks. Now, they have to face a Buffalo defense that leads the league in sacks (43). Rookie Mike Glennon isn't the most mobile quarterback around and this matchup could be a big advantage for the Bills. The Bucs are going to have to get some blocking help from their tight ends and running backs. The Bucs always talk about taking shots deep down the field. But this might be one game where they should get away from that because Glennon might not have enough time to throw the deep ball.
Buffalo's running game: One of coach Greg Schiano's keys to any game is stopping the run. That might be difficult against a Buffalo ground game that ranks No. 4 in the league. Tampa Bay ranks No. 12 in stopping the run and the Bucs will need big games from players such as defensive tackle Gerald McCoy and linebackers Lavonte David and Mason Foster.
Bobby Rainey: The running back has been silenced the past two games after rushing for 163 yards against Atlanta. Since then, Rainey has averaged 49 yards a game. The problem hasn't been Rainey. The problem has been that opposing defenses are loading the box against the running game. The offensive line has to start giving Rainey some room to run.