Something will have to give when the teams meet Sunday at Lucas Oil Stadium.
The Colts can basically lock up their first division title since 2010 with a victory, because they would have a three-game lead on the Titans with four remaining. A win by the Titans would cut Indianapolis' lead to one game.
ESPN.com Colts reporter Mike Wells and Titans reporter Paul Kuharsky break down the matchup.
Wells: The Titans made things in the division a little more interesting when they came from behind to beat Oakland last weekend. But they will be without a key player this weekend. How much will losing safety Michael Griffin impact the Titans' defense this weekend?
Tennessee Titans at Indianapolis Colts
Sunday, 1 p.m. ET
Kuharsky: They are OK without him, as George Wilson is a capable veteran safety who will start in his spot. Wilson played for an injured Griffin in St. Louis, which was a bad game for Tennessee, but not because of that switch. Wilson has covered tight ends in a heavy nickel set and the dime package for much of the season, and the Titans have been better against tight ends after having huge problems in 2012. The Titans didn’t use Wilson against Coby Fleener two weeks ago. Wilson played only one defensive snap in that game, and the Titans let their base defenders deal with Fleener. They didn’t fare well, as he caught eight passes for a game-high 107 yards. Using Wilson as they have against other teams is not an option now, since he’s in line to start.
Let’s stay in the secondary. Has Vontae Davis been consistent? And how is his health now?
Wells: Inconsistent is a better word to describe Davis. He looked like he was on his way to earning a nice offseason payday earlier this season. But he hasn’t been the same since Greg Toler, who starts opposite of him at cornerback, went down with a groin injury four games ago. It’s like Davis feeds off of Toler’s presence on the field. Houston's Andre Johnson, St. Louis' Tavon Austin, and Arizona's Larry Fitzgerald all took turns getting the best of Davis at times in three of the past four weeks. Davis' groin injury isn’t severe, so he should be in the lineup this weekend. There is a chance that Toler could be back, too.
Running back Chris Johnson had a monster first half in the previous meeting against the Colts. But the Titans stopped handing the ball to him in the second half. Do you think the same thing will happen this weekend if Johnson has another strong first half?
Kuharsky: Well, the Colts came out and scored, collected Devon Wylie's kickoff fumble, and scored again, erasing the Titans' lead. I’m thinking Leon Washington, who was just signed to replace Wylie, will be more reliable, and the Titans won’t go so long without having the ball on offense. With Ryan Fitzpatrick finding a rhythm at quarterback, they are more likely to throw some short passes that function as runs. The Titans will certainly want to run it. But they don’t sustain it very well when they do manage to get it going some.
The Titans jumped out to that lead last time after the Colts were coming off getting blown out by 29. Now they draw the Colts after the Colts were blown out by Arizona. The Colts usually bounce back well, but I sense that the faith of those close to the team is waning. Is the team starting to doubt itself?
Titans at Colts: Stat of the Week
The number of times the Colts have been penalized this season. They are the least penalized team in the league.
Wells: Faith better not start waning after owner Jim Irsay was, well, Jim Irsay and voiced his frustration Tuesday on Twitter about the team’s performance the past few weeks. The Colts have yet to lose back-to-back games with Andrew Luck as quarterback, but this was a different Colts’ team inside the locker room after the Arizona game. They normally talk among each other win or lose after the game. There was very little of that this time. Players showered and dressed rather quickly and headed toward the bus. The Colts are very vulnerable right now. The Titans have an excellent opportunity to come to Lucas Oil Stadium and win the game. All the pressure in the division race would shift to the Colts if that happens.
You mentioned that Fitzpatrick is finding his rhythm. Do you think this could lead to a quarterback controversy next season with him and Jake Locker?
Kuharsky: Well, we aren’t sure yet that the same coaching staff or regime will be in place. Presuming it is, and presuming Locker recovers fully and on schedule from his Lisfranc surgery, he’ll begin next year at the front of the line. The question isn’t so much about the possibility that Fitzpatrick surpasses him -- he’s very much a backup -- it’s about whether the Titans are compelled to deem Locker injury-prone and draft an alternative/possible replacement. Based on what they have seen so far, they can't execute a very expensive option in May for the 2015 season, so they also have to be looking ahead.
The Colts have had some serious injuries, too. Reggie Wayne was a terrible guy to lose. Would tight end Dwayne Allen rank a close second?
Wells: Don’t get me wrong, not having Allen is a significant blow to the Colts, but I’d say losing guard Donald Thomas is second on the list. The offensive line was abysmal last season, and the Colts went out and spent money to upgrade it during the offseason, with Thomas and tackle Gosdar Cherilus being the main pieces. The Colts went from starting Thomas, a veteran, to starting rookie Hugh Thornton. That’s a drastic drop-off, especially since Thornton shifted to left guard on the fly because he played right guard in college. The entire offensive line has been inconsistent with its run and pass protection this season.
The final word on Sunday's matchup at Lucas Oil Stadium:
Paul Kuharsky: I won't be at all surprised if the game follows the form of the last one -- with an early lead for the Titans and a winning rally from the Colts. Can the Titans finally break through against Indy and be the first team to beat the Andrew Luck Colts a week after the Colts lose? I'm tempted to say yes, but I can't. Colts 27, Titans 24
Mike Wells: The Colts are a vulnerable team. Their owner called them out on Twitter, and they are coming off a blowout loss. The St. Louis Rams beat them by 30 points on Nov. 10. And just like when they faced the Titans days after that loss, the Colts will do just enough to beat the Titans again. Colts 21, Titans 17