Appearing on SiriusXM radio, Calhoun flatly said "I'm not interested" when asked about the BC job, although he did say he would consider coaching again in the right circumstances.
"I would think about coaching, but it has to be the perfect situation," he said. "I don't have to go hunting for a job. That's not really what I'm desiring to do. But if something special came along, I feel I still have enough zip, power and certainly love for the game, love for competition, that I'd do it. But it'd have to be the right situation for me and for that school.
"At this particular point I just don't know if I would find the answer at Boston College. Nothing against Boston College, it's a great school, it's a terrific school in what will be, in my opinion, the best basketball conference in America.
"I have not talked to the people at BC. BC has not talked to me. You could imagine that with all my Boston ties a lot of people have called me. That's kind of a normal thing, that happens with folks. I will never say never because I love the game and the right situation for me and for the school I would think about. But at this point I'm not interested."
Calhoun, 71, stepped down before the start of last season, after having suffered a broken hip in a bike-riding fall. The defending champion Huskies went 20-14 in his final season, losing in the first round of the NCAA tournament.
He is a native of the Boston suburb of Braintree and coached at Northeastern from 1972 to 1986.
Boston College parted ways with Steve Donahue earlier in the week after four years and a 54-76 mark. The Eagles were 8-24 this season, 4-14 in Atlantic Coast Conference play.
ESPN previously reported that Calhoun had an interest in the Eagles' coaching vacancy.