With the Red Sox due to face three more left-handers on their homestand, manager John Farrell said Drew may get a day off until he's back to every-day availability.
To make room for Drew, the Red Sox optioned Brock Holt back to Triple-A Pawtucket. Farrell praised Holt for his contributions and predicted he'll be back to help, but said the club preferred Brandon Snyder's right-handed bat against lefties.
Right fielder Shane Victorino, who came out of Friday night's game with a tight left hamstring, was not in Saturday's lineup and remains day to day. Farrell said the hope was Victorino would be back in the lineup Sunday.
Holt batted .290 in 10 games with nine singles in 31 at-bats. He made nine starts at third base, with Jose Iglesias playing shortstop. With Drew back, Iglesias slides back to third.
"I am excited," Drew said. "It's kind of frustrating that I had to go on the DL but it's part of the game and I'm looking forward to getting back and getting back in the routine."
Drew was challenged on the game's first play when Brett Gardner of the New York Yankees hit a bouncing ball over the mound. Drew ranged to the second-base side of first and made a strong throw, but Gardner just beat it, sliding into first.