Mayo did not work out with the team on Wednesday, two days after being injured in a 25-24 win over the Buffalo Bills. He suffered a sprained medial collateral ligament and could miss up to eight weeks, the Boston Globe reported.
Mayo's agent, Sean Kiernan, did not return an e-mail seeking comment. The Patriots gave no details other than to say Mayo didn't practice.
Last year's NFL defensive rookie of the year was hurt with just over four minutes left in the first quarter. Afterward, he walked along the sideline under his own power but did not return to the game.