The Bruins, 16-4-2 at home, saw their eight-game winning streak in Boston come to an end with a 5-3 loss to the New York Islanders on New Year's Eve. They hadn't allowed more than four goals in a contest at home, where they had surrendered just six goals over their last six.
Boston (26-12-2) squandered a 3-1 lead, yielding four goals in the final 23:30 of play -- three of which came on power-play chances.
"Some of those penalties are penalties that ended up hurting us a lot down the road, so we have to take ownership of that," coach Claude Julien said.
The Bruins, who entered with the league's third-best penalty kill at 87.1 percent, surrendered four goals on eight power plays, both season worsts. The Atlantic Division leaders had given up as many power-play goals over their previous 15 home games.
"We knew they had a good power play and we didn't do a good job on the PK," said Patrice Bergeron, who scored his 10th goal for his sixth point in six games. "We can give them credit but still, we could've played a lot better."
Nashville lost the teams' first meeting since March 17, 2011, despite claiming a 34-33 advantage in shots.
The Bruins will be matched up against a hot power play. The Predators have scored 10 times on 34 chances over their last nine games following a 1-for-21 slump.
However, Boston could have a big advantage when on the power play, having gone 8 for 20 in the last seven games. Nashville's last seven opponents are 8 for 21.
The Predators (18-18-4) had matched a season high with five straight losses before winning their last two games, including a 6-4 home victory over Detroit on Monday. Colin Wilson had two goals and an assist while Mike Fisher scored and recorded two assists after also finishing with three points in Saturday's 3-2 win over Los Angeles.
Both Nashville and Detroit scored three goals in the final period. The Predators improved to 15-1-2 when scoring first.
"That's the sign of a good team, playing against a good team like that, we can win one in the third there," Fisher said.
Iginla has 10 points in his last nine games versus Nashville.
The Bruins have won four of the last five meetings in Boston.