Tom Brady vs. Peyton Manning -- Ranking Each Matchup

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10. Nov. 21, 2010: Patriots 31, Colts 28

Photograph By AP Photo/Stephan Savoia

Manning threw for 396 yards and four touchdowns, but defensive back James Sanders ended a potential game-winning drive when he picked off a Manning pass near the end zone to seal the win for the Patriots. "I feel sick about it," Manning said. "About not extending the game, not executing to give [kicker Adam] Vinatieri a chance for a field goal. It was a bad throw."