May 4, 2013 // 9 p.m. ET (Showtime PPV)
MGM Grand, Las Vegas
Guerrero has a legitimate chance, but I can't bring myself to pick him. Floyd is the king until proven otherwise. It'll be a tough fight, but Mayweather wins on points.
Guerrero will give everything and he'll make sure Mayweather knows he's in a fight. But he'll take too many inside uppercuts in the process, and Floyd will stop him late.
Guerrero will be faster and more active than usual, and he'll try to make an early charge. But once Mayweather finds his rhythm, he'll dominate the fight and win a decision.