Guzman, 28, will try to rehabilitate the shoulder after surgery. The history of return from ligament surgery in a pitcher's throwing shoulder is not good.
An MRI on Friday revealed a tear in Guzman's shoulder, and it is related to an injury that caused the Cubs to shut him down with two weeks left in the 2009 season.
Andrews repaired Guzman's torn labrum in 2003 and performed Tommy John surgery on the pitcher's right elbow in 2007.
Guzman is coming off his best season -- a 2.95 ERA in 55 appearances -- and was expected to be the righty setup man in front of closer Carlos Marmol. Now Piniella will spend the rest of preseason conducting auditions for that role.
The injury is only the latest trouble for Guzman, whose brother, Daniel, died in his arms two months ago after being shot in their native Venezuela. Guzman then underwent arthroscopic knee surgery a few days later for an injury he sustained while running.
ESPNChicago.com's Bruce Levine contributed to this report. Information from the Associated Press was used in this report.