Konerko hit a two-run homer in the first and was back at the plate in the third inning. Samardzija's high pitch, which he said was a splitter, sent him sprawling to the ground. Konerko stayed down for several minutes before he was able to walk off the field, holding a towel to his face.
Konerko suffered a small laceration over his left eye and some swelling. He was to undergo further tests. Comcast SportsNet Chicago reported after the game that Konerko suffered no vision issues.
"It's unfortunate," Samardzija said. "There are a lot of superstars in this league that put up big numbers and get paid a lot of money, and Paulie is one of those guys who does that and is a superstar and does it the right way. There aren't too many of those guys out there. He's not about show, he's not about himself.
"Paulie's a great guy. That ball got away, and unfortunately it hit him up high. If I could take it back, I would. Only thing that makes me OK about it is he's a tough guy. I hope he'll be alright, and I wish I could have that one back."
Dayan Viciedo went in to run for Konerko and took over in left field with Adam Dunn moving from left to first. Konerko's homer was his 19th in 66 games against the Cubs since joining the White Sox in 1999. He came into the game batting .362, third-best in the American League.
White Sox catcher A.J. Pierzynski saw Konerko before he departed the stadium. Pierzynski checked on Konerko in the team's clubhouse during the fourth inning.
"His eye was pretty swelled up, but he was cognizant and didn't say he was dizzy or anything," Pierzynski said. "I've seen him get hit before, get up and go to first. It was little scary when he didn't get right up. He seemed fine, and we'll see how he feels (Saturday).
"Once you lose Paul, it kind of shellshocks you a little bit because he's such a steady force. He's always in the lineup. He's always there, and he always hits. When you take him out, Viciedo came in, Dunn moved to first. We're lucky we have those kind of options, but Paul will always be missed no matter how long he's out. Hopefully, it's shorter than longer."
White Sox manager Robin Ventura said he will use Dunn at first and Viciedo in left field if Konerko needed to miss any additional time in the Cubs series.
Information from ESPNChicago.com's Scott Powers and The Associated Press was used in this report.