Francisco Liriano will pitch against his former team Saturday in place of Jose Quintana. Quintana will get two extra days rest and pitch against Detroit. Gavin Floyd also will get the extra day as he will pitch in Kansas City on Tuesday.
The changes are about rest and matchups for the Sox pitchers as they look forward to the last 20 days of the season.
"When we flew up here, we talked about a lot of different things," manager Robin Ventura said. "We are going to switch around; this feels like the right thing to do. We are also taking care of Quintana; he threw a lot of innings last time out. He has pitched well against (the Tigers) but you are protecting him and giving him an extra couple days.
A day earlier, the White Sox said Liriano was going to be skipped in the rotation and remain in the bullpen.
The Sox will most likely stay the course with the rotation since they do not have an off day the rest of the regular season. Chicago also has the luxury of having three pitchers in the bullpen that can spot start if they are needed. Hector Santiago, Phil Humber and Dylan Axelrod have all started games for the Sox this season. Humber pitched a perfect game April 30 in Seattle.
"This is what we are going to go with for now," said pitching coach Don Cooper. "Who knows? Three or four days from now it might change."
Going into Friday's game, the White Sox had lost nine out of their past 10 road games and four straight as they begin a nine-game road trip interrupted only by Monday's makeup game in Chicago.
The White Sox recalled right-hander Jhan Marinez from Triple-A Charlotte before the game, giving them 18 pitchers on their active roster.
Information from The Associated Press was used in this report.