Konerko said the procedure will remove a bone fragment from the wrist. The surgery will be performed at Rush University Medical Center in Chicago.
Konerko, who is batting .299 with 25 homers and 73 RBIs in 143 games, wasn't in the lineup for Tuesday's game against the Indians. He was sidelined for three games in June to have debris flushed from a joint that was causing pain in the wrist, but said it hasn't bothered him since.
Manager Robin Ventura said Konerko might be in the lineup for the final game of the season Wednesday.