Hamilton left the floor about 90 seconds into the Bulls' 92-72 victory over the Indiana Pacers on Monday, walking directly into the tunnel leading to the Chicago locker room while holding the shoulder. He was replaced in the lineup by Ronnie Brewer.
Hamilton, in his first season as a Bull, was looked at as the potential missing piece in Chicago's quest for an NBA title but has played in just 16 of the team's 40 games because of nagging injuries. He's averaging 12.1 points, fourth-best on the Bulls.
The Bulls play the Milwaukee Bucks on Wednesday.
Information from The Associated Press was used in this report.