Rose, who has been out the past three games with a sore right foot, missed his 26th game of the season.
"He's feeling a lot better today, but he's still not quite there so we're just going to be patient and when he's ready to go, he'll go," Bulls coach Tom Thibodeau said before the game.
Heat forward Chris Bosh was inactive for Thursday's game against the Bulls. He previously had been listed as a game-time decision by Heat coach Erik Spoelstra.
"There's nothing major, just minor bumps and bruises," Spoelstra said before the game.
Deng, who missed Wednesday's game against the Charlotte Bobcats, scored 11 points on 5-of-15 shooting in a team-high 40 minutes on Thursday.
After missing 13 of the previous 14 games with a sore groin and ankle, Rose returned to play the Heat on April 12, but struggled mightily, missing 12 of 13 shots and finishing with a career-low two points. But the Bulls beat the Heat in overtime thanks largely to the play of Rose's backup, C.J. Watson, who scored 16 points and hit the game-tying three-pointer that sent the game into overtime.
This marks the fifth game that Bosh has missed this season. The Heat are 3-2 in games without Bosh this season.
"I'm just trying to survive," Rose said with a chuckle Wednesday morning. "I'm actually all right, getting better. The story of my life, just getting treatment, waking up at 9 every day. I turned myself into a morning person. Just trying to stay focused and hopefully I'll be out there."
The Bulls have gone 17-9 without Rose, who said he doesn't want to sit the rest of the regular season.
Information from ESPN.com's Tom Haberstroh was used in this report.