Wade missed the past two games with a bruised right knee and spent Tuesday and Wednesday morning in Chicago receiving treatment. He injured the knee during a March 6 win against Orlando and aggravated the bruise last week in a win at Boston.
The Heat currently are in the middle of the second-longest winning streak in league history at 27 games, just six short of matching the 33-game streak set by the Los Angeles Lakers during the 1971-72 season.
Wade said after Wednesday's shootaround that the soreness in his right knee represents one of two ailments he has been dealing with recently, but he would not disclose what the other issue was other than saying it has subsided.
"I'm going to give it a go," Wade said after the workout in the United Center. "I had two situations that I was dealing with and one of them is gone. The other one [knee], I'm still dealing with and it's not going to go away today. So I'll get back out there to play and see how it feels."
The Bulls are also dealing with injury concerns, with starting center Joakim Noah considered a game-time decision as he recovers from a foot injury. Chicago will also be without guards Marco Belinelli, Richard Hamilton and Derrick Rose.
"Same, just taking my time and that's about it," Rose said when asked about his surgically repaired knee. "Been the same way for a couple of months now.
"I really don't know, man [when he'll return]. Like I said, it's in God's hands. Every day I'm just waking up to try to be the best player, try and produce every time I step on the court, just try to get better as a player and who knows when."
Wade has averaged 21 points, five rebounds and five assists in 64 games and is shooting a career-high 51.9 percent from the field this season. In addition to having a chance to play in his hometown, Wade also has another incentive to get back on the court. The 10-year veteran shooting guard has partnered with best-selling author James Patterson to donate 1,000 books to a charity youth group in Miami for every point he scores Wednesday against the Bulls.
"Even if I score one point, it's a great deal," Wade said.
ESPNChicago.com's Doug Padilla contributed to this report.