Seabrook was hit from behind, falling into the boards then onto the ice after Flames' forward Rene Bourque hit him with 4:35 remaining in the first period.
Replays appeared to show Seabrook suffered a head injury, the extent of which is unknown. It would be the third time in three years he has absorbed a hit to his head.
Blackhawks coach Joel Quenneville said Seabrook "seemed not bad after the game," adding his exit from the game was more precautionary.
"We'll see," Quenneville said. "We'll find out more tomorrow, but I think he seemed alright. I just talked to him. Seemed OK."
Blackhawks defenseman Duncan Keith added: "Seabrook is doing a lot better."
Jesse Rogers covers the Blackhawks for ESPN 1000 and ESPNChicago.com.