His backup, redshirt freshman Skyler Mornhinweg, will again make the start.
In Mornhinweg's second career start last week, Florida dropped to 4-7, 3-5 in SEC play, with a stunning 26-20 loss to Georgia Southern. He completed 14 of 25 passes for 122 yards with two touchdowns and no interceptions.
Murphy, who sprained the AC joint in his throwing shoulder in the LSU game on Oct. 12 and aggravated it in the Gators' Nov. 9 loss to Vanderbilt, led UF to a 2-4 record in six starts after starter Jeff Driskel was lost for the season with a broken bone in his lower right leg.
Information from ESPN's Joe Schad and ESPN.com's Jeff Barlis was used in this report.