The first game between the teams will take place Sept. 26, 2015, at the Carrier Dome in Syracuse, N.Y. LSU will host the second game on Sept. 9, 2017.
"We are thrilled to enter into this home-and-home agreement with a premier program like LSU," Syracuse athletic director Daryl Gross said in a statement. "Student-athletes come to Syracuse to play on the biggest stage possible, and this gives our coaches and young men the chance to battle one of the standard-bearers of the SEC on our home turf.
"It is a complicated process to arrange games of this magnitude, and I couldn't be happier for our fans and for all who will be involved in this upcoming series."
The 2015 game will be the first regular-season contest between the schools. They have met twice in bowls -- Syracuse won the 1989 Hall of Fame and LSU won the 1965 Sugar.
The Tigers will face the Orange at the Carrier Dome in Syracuse, N.Y., on Sept. 26, 2015, during the fourth week of the season. Syracuse will make the return trip to Tiger Stadium on Sept. 9, 2017.
"This is another attractive nonconference series that our fans will enjoy and our football program will benefit from," LSU athletic director Joe Alleva said, according to the school's website. "To be able to bring LSU football to the northeast part of the country for a football game will be a unique experience and then to have Syracuse return the trip to Tiger Stadium in 2017 will be a nice addition to our home schedule."