Coach Brian Kelly said after the game that Collinsworth has a Grade 2 MCL sprain and is expected to miss two to four weeks. He was hurt while in the two-minute drill Thursday when he came down awkwardly. His MCL tightened on the next play.
Collinsworth, a fifth-year senior who was named one of the four team captains earlier this week, arrived at the stadium Saturday in a golf cart and was holding crutches.
He is the son of NFL broadcaster Cris Collinsworth. He has 68 career tackles, three passes defended and one forced fumble.
Junior Elijah Shumate started in Collinsworth's place. Shumate had 23 tackles last season, including a career-high seven against Oklahoma.
Notre Dame already entered Saturday's game without five players who are being held out as the school concludes its internal investigation into academic misconduct: wide receiver DaVaris Daniels, cornerback KeiVarae Russell, defensive end Ishaq Williams, linebacker Kendall Moore and safety Eilar Hardy.