The former Heisman Trophy frontrunner injured the knee on a 6-yard run with a little more than five minutes remaining in the fourth quarter and Georgia leading 27-7.
The junior was seen sitting on the Bulldogs' training table on the sideline with ice on the knee and was being comforted by a handful of players.
He left the field on a cart after the game.
Coach Mark Richt said he didn't know the extent of Gurley's injury.
"He hurt his knee," Richt said. "We'll just have to see what it was.
"I'm just as curious as everybody else."
Richt said he expected Gurley to have X-rays on the knee later Saturday night.
"That would be my guess," he said. "I just don't know."
Saturday was Gurley's first game back for the Bulldogs after serving a four-game NCAA suspension for taking $3,000 for autographed memorabilia and other items over the course of two years.
Gurley rushed for 138 yards and a touchdown on 29 carries against the Tigers before leaving.
On the season, Gurley has rushed for 911 yards and nine touchdowns.