Oregon State officials said Wednesday night the game will be rescheduled.
The Nicholls State campus in Thibodaux, La., is closed because of Isaac, and classes Friday already have been canceled. The team was scheduled to take a charter flight to Oregon on Friday morning.
"It's extremely unfortunate that we will not be able to make this trip," Nicholls State athletic director Rob Bernardi said in a statement. "With the lingering effects of Hurricane Isaac, we do not want to put any of our student-athletes or staff in danger, so at this point, we feel like it is best to focus on the safety of everyone, and we'll look into rescheduling the game at a later time."
Lafourche and Terrebonne parishes in Southern Louisiana were hit hard by heavy wind and rain from Isaac on Wednesday, leaving some 60,000 homes and business in the area without power. The slow-moving storm that caused widespread coastal flooding was later downgraded.
Officials for the two schools will now consider options for rescheduling the game. Because the teams have different off dates, the game could be scheduled for the weekend of Dec. 1, but there could be a conflict if the Colonels reach the FCS playoffs or the Beavers go to the Pac-12 championship.
Pac-12 officials also will be involved in rescheduling the game.
The two schools originally planned to decide whether to postpone the game Thursday night. Options included playing on Sunday or Monday.
"It became apparent as the day progressed that the safety of Nicholls State's team and personnel was a primary concern," Oregon State athletic director Bob De Carolis said in a statement. "Many of the Colonels' student-athletes and staff are with family and there is a deepening concern about their safety in returning to campus."
The Beavers will now open the season at home Sept. 8 against No. 12 Wisconsin. The Colonels open at South Alabama that day.