Coach Mark Richt dodged questions throughout the preseason as to whether the two defensive starters would be available after reports during spring practice that they failed drug tests and would face suspensions.
But the Bulldogs will indeed play their first game without six expected starters, including the two defensive standouts.
Rambo led the SEC and finished second nationally with eight interceptions in 2011. Ogletree missed half the season with a broken foot but led the Bulldogs in tackles in each of the last five games.
Senior receiver Marlon Brown is also unavailable for the Bulldogs with what a UGA spokesman said is a hamstring strain.
UGA announced on Friday that starting cornerback Malcolm Mitchell will miss the opener with a sprained ankle.