Burkhead left this past Saturday's game against Northwestern in the first quarter. He initially sustained a sprained ACL in the knee Sept. 1 in the season opener and missed two games.
He performed well in his return until aggravating the knee Oct. 6 against Ohio State.
Huskers coach Bo Pelini said this aggravation isn't as bad as the one in the Ohio State game, but the repeated issues have him inclined to rest Burkhead for a week. Pelini said Burkhead is day to day and has improved since Saturday.
"He felt really good going into the [Northwestern] game, didn't have any issues in practice," Pelini said. "He's frustrated and obviously disappointed he's had to deal with it. It's been too bad."
Pelini said Burkhead's input will be taken into account in determining his status against Michigan (No. 22 BCS, No. 20 Associated Press).
Burkhead has 43 carries for 392 yards and three touchdowns this season. Ameer Abdullah has filled in well for Burkhead, leading Nebraska (5-2, 2-1 Big Ten) with 514 rush yards and seven touchdowns on 86 carries.