As part of Notre Dame's move to the ACC in all sports but football, the Fighting Irish will play five games annually against ACC opponents starting in 2014.
The addition of Notre Dame to the ACC's schedule will be a boost for the league in the all-important strength of schedule component in the new playoff format beginning in 2014.
"The football partnership between the ACC and Notre Dame will not only enhance our league's already ambitious football schedules but also will provide terrific fan excitement," ACC commissioner John Swofford said in a statement.
"One of the benefits, moving forward, is that almost all of our student-athletes will have an opportunity to play against Notre Dame during their ACC careers, which is extremely special."
With Notre Dame's scheduling agreement, every ACC team is guaranteed to play the Fighting Irish once every three years, and each ACC school will host Notre Dame at least once every six seasons.
Notre Dame never has played Louisville or Virginia Tech and hasn't faced Clemson since 1979 or Virginia since 1989.
The exact dates for each game are still to be determined.