| Passing Leaders | |||||||||
| RK | NAME | TEAM | RESULT | COMP | ATT | YDS | TD | INT | RAT |
| 1 | Case Keenum, QB | HOU | W 50-43 vs. USM | 44 | 54 | 559 | 5 | 1 | 195.3 |
| 2 | Trevor Vittatoe, QB | UTEP | L 33-38 vs. UAB | 24 | 45 | 419 | 2 | 2 | 137.3 |
| 3 | Adam Weber, QB | MINN | W 42-34 vs. MSU | 19 | 31 | 416 | 5 | 1 | 220.8 |
| 4 | Levi Brown, QB | TROY | W 42-21 vs. ULM | 28 | 41 | 378 | 4 | 0 | 177.9 |
| 5 | Bryant Moniz, QB | HAW | L 21-31 at NEV | 29 | 49 | 374 | 3 | 2 | 135.3 |
| 6 | Spencer Keith, QB | KENT | W 26-14 vs. WMU | 24 | 34 | 373 | 2 | 2 | 170.4 |
| 7 | Kyle Padron, QB | SMU | W 27-13 at TLSA | 20 | 30 | 354 | 2 | 0 | 187.8 |
| 8 | Kevin Riley, QB | CAL | W 23-21 at ASU | 27 | 44 | 351 | 2 | 0 | 143.4 |
| 9 | Russell Wilson, QB | NCST | L 42-45 at FSU | 20 | 30 | 349 | 5 | 2 | 206.1 |
| Riley Skinner, QB | WAKE | L 27-28 vs. MIA | 29 | 43 | 349 | 2 | 1 | 146.3 | |
| Rushing Leaders | |||||||||
| RK | NAME | TEAM | RESULT | CAR | YDS | YPC | TD | ||
| 1 | Bernard Pierce, RB | TEM | W 27-24 at NAVY | 29 | 267 | 9.2 | 2 | ||
| 2 | Anthony Dixon, RB | MSST | W 31-24 at UK | 33 | 252 | 7.6 | 2 | ||
| 3 | Lance Dunbar, RB | UNT | W 68-49 vs. WKU | 23 | 227 | 9.9 | 1 | ||
| 4 | Dexter McCluster, RB | MISS | L 20-33 at AUB | 22 | 186 | 8.5 | 1 | ||
| Jermaine Thomas, RB | FSU | W 45-42 vs. NCST | 20 | 186 | 9.3 | 2 | |||
| Jonathan Dwyer, RB | GT | W 56-31 at VAN | 22 | 186 | 8.5 | 3 | |||
| 7 | Ryan Mathews, RB | FRES | W 31-27 vs. USU | 23 | 185 | 8.0 | 2 | ||
| 8 | LaMichael James, RB | ORE | W 47-20 vs. USC | 24 | 183 | 7.6 | 1 | ||
| 9 | Jeremiah Masoli, QB | ORE | W 47-20 vs. USC | 13 | 164 | 12.6 | 1 | ||
| Donald Buckram, RB | UTEP | L 33-38 vs. UAB | 28 | 164 | 5.9 | 2 | |||
| Receiving Leaders | |||||||||
| RK | NAME | TEAM | RESULT | REC | YDS | YPR | TD | ||
| 1 | Jerrel Jernigan, WR | TROY | W 42-21 vs. ULM | 13 | 203 | 15.6 | 1 | ||
| 2 | Tyshon Goode, WR | KENT | W 26-14 vs. WMU | 11 | 198 | 18.0 | 2 | ||
| 3 | James Cleveland, WR | HOU | W 50-43 vs. USM | 13 | 190 | 14.6 | 2 | ||
| 4 | Gerald Baptiste, WR | USM | L 43-50 at HOU | 8 | 186 | 23.3 | 3 | ||
| 5 | Owen Spencer, WR | NCST | L 42-45 at FSU | 5 | 165 | 33.0 | 1 | ||
| 6 | Tim Brown, WR | RUTG | W 28-24 at CONN | 5 | 162 | 32.4 | 2 | ||
| 7 | Jeff Moturi, WR | UTEP | L 33-38 vs. UAB | 7 | 161 | 23.0 | 0 | ||
| 8 | Brandon Banks, WR | KSU | L 30-42 at OKLA | 9 | 156 | 17.3 | 0 | ||
| 9 | Marvin McNutt, WR | IOWA | W 42-24 vs. IND | 4 | 155 | 38.8 | 1 | ||
| 10 | Andre Jones, WR | AKR | L 10-27 at NIU | 6 | 154 | 25.7 | 1 | ||
