SAN FRANCISCO -- 49ers star tight end Vernon Davis did not return to Sunday's 10-9 loss to Carolina after suffering a concussion on a dropped pass in the second quarter.
The team announced in the third quarter he would not return.
Davis missed the game against the Colts in Week 3 with a hamstring injury, which is the last game the 49ers have lost.
Davis is having a career year. He has 29 receptions for 518 yards and seven touchdowns this season.
The 49ers have one healthy tight end for the rest of the game -- rookie Vance McDonald. Garrett Celek was ruled out in the first quarter with a hamstring injury.
The Niners first-round pick, safety Eric Reid, also left the game with a concussion. He had a brutal collision with Panthers running back Mike Tolbert.
It is the second concussion of the season for Reid, who has been terrific as a rookie. He suffered one at Seattle in Week 2.