Hamilton did pinch hit, however, walking in the Rangers' 4-1 loss.
Rangers officials said Saturday that Hamilton is getting extra recovery time after the slugger left Friday night's game early with knee pain.
Hamilton said he received a cortisone shot on Sunday and can already feel a difference. Manager Ron Washington said he expects Hamilton to be back in the lineup on Tuesday.
"We'll give him these two straight days to rest it and he'll be back in there," Washington said.
He got a shot in May and it helped calm the knee down for a few months. The hope is that this shot will do the same and keep the leading hitter in the majors with a .362 average feeling good through the end of the season and into the postseason.
"It's not really a pain issue. It's not something I can't deal with," Hamilton said. "It just gives out on you at times that it need not to give out on you. If it doesn't work right, it's frustrating. It can't really happen, especially in the situation we're in as far as playing in our division and on this road trip and needing to be able to perform baseball functions."
Hamilton said he talked with Washington during Friday's game about playing in an outfield corner to protect his knee. He started in center, moved to left field in the fifth inning and was taken out in the seventh.
He has played in center 26 times this season.
David Murphy replaced Hamilton in left Saturday. He went 1-for-3 with a walk and scored a run.
Also in the lineup Saturday night were two recent acquisitions made their first starts for the Rangers, first baseman Jorge Cantu and second baseman Cristian Guzman. Cantu went 1-for-4 while Guzman was hitless and struck out twice in four at-bats.