It's the third straight game that Hamilton has missed as he nurses a stiff back, and it's the second straight for Beltre, who has dealt with hamstring issues this season.
Manager Ron Washington said on ESPN Dallas 103.3 FM's "Ben & Skin Show" that the turf at Rogers Centre in Toronto is part of the reason for holding out both players, who he said are day to day.
"Beltre can pinch hit, but I'm trying to keep him off this turf," Washington said. "Hopefully, his body can settle down by the time we get to Cleveland and he can play Friday. But this turf just beat him up so bad that he's so sore. But I do have him to pinch hit for me."
Washington also has made it a habit of resting some regulars on day games before off-days to give them additional time off their feet. He said his club isn't used to playing on turf, which is why he takes a cautious approach if players are dealing with some injuries.
"When you play on turf, it's a little different if you're playing on it every day and coming up in here for a series and you haven't been used to it. It shocks your body," he said. "Everybody's dealing with soreness the past three days, but we're not using that as an excuse to not win a ballgame."
Washington also said that catcher Mike Napoli's eye is fine and that he's ready to play. Napoli is in the lineup at first base Wednesday.
Napoli tweeted Wednesday that he had an ocular migraine during Tuesday's game. Washington said the medical staff told him about Napoli's vision issue in the eighth inning and they decided not to play him in the ninth.