Beltre hit his first homer on Wednesday night leading off the second against Tommy Hunter. With that long ball, he became the ninth third baseman in major league history with 10 seasons of at least 20 home runs.
Beltre grounded out to third in the sixth inning and grounded into a double play in the eighth.
On May 8, Hamilton became the 14th player all-time to hit a record four home runs in a game. His feat also came against the Orioles, in Baltimore.
Information from The Associated Press was used in this report.