Harden, who leads the team in scoring with 23.9 points a game, will sit out Monday night with a sprained left ankle. Lin has missed four games recently with back spasms.
"It is what it is and we just have to play through it," Dwight Howard said, according to the Houston Chronicle. "It is a long season. There are going to be a lot of injuries."
Information from The Associated Press was used in this report.