The Indianapolis Colts remained perfect with a win over Jacksonville. Peyton Manning threw four more touchdowns.
Browns running back Jerome Harrison ran for 286 yards while teammate Joshua Cribbs returned two kickoffs for touchdowns.
Ben Roethlisberger threw for over 500 yards, including a last-second touchdown for the Steelers in a wild win over Green Bay.
The Dallas Cowboys ended that "December swoon" by winning in New Orleans.