Monday night, Rodgers and the Packers cost him a chance to win $1 million.
Reynolds picked Green Bay over New Orleans in an attempt for his 25th straight win in ESPN's Streak for the Cash game. But the Saints, playing at home on Monday Night Football, beat the Packers 51-29 to make Reynolds the second player to lose after reaching 24 wins.
Bigsam112 is now the leader with a streak of 23 straight wins. He picked the Saints on Monday.
Reynolds got to 24 consecutive wins on Sunday night in dramatic fashion, when Indianapolis beat San Diego on a last-second field goal. Earlier in the day, he reached 23 wins when the Baltimore Ravens routed the Philadelphia Eagles 36-7.
Reynolds' streak began Oct. 24 when Stardom Bound won the Juvenile Fillies in the Breeders Cup. He got a second horse racing win when Zenyatta won the Ladies Classic.
Reynolds, a graduate of Cal Poly San Luis Obispo and a San Francisco Bay Area sports fan, won two games Saturday (Clemson and Boston College). He's won nine times with college football picks. He also picked up a win with Brock Lesnar over Randy Couture in MMA on Nov. 15.
Jordan Fulkerson of Louisville, Ky., had 24 wins before picking Carolina. Katie Kaufmann of Minneapolis had 23 wins before also picking the Panthers.
Scott Conant of Moscow, Idaho, who had 23 wins heading into Saturday, lost his streak when he picked Wake Forest to beat Boston College.