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Larry Nance Jr. suffered a knee injury Tuesday night, putting a damper on Wyoming's 72-66 victory over Fresno State.
Nance, son of the former All-Star forward for the Phoenix Suns and Cleveland Cavaliers, had 17 points on 7-of-9 shooting before he crashed to the floor with 14:51 to play.
The Cowboys' leader in scoring, rebounds, blocks and steals laid on the court for several minutes holding his right knee before being helped off, unable to put any weight on the leg.
Nathan Sobey scored a career-high 26 points as Wyoming (17-9, 8-5 Mountain West) won its third straight. The Cowboys grabbed the lead for good when Josh Adams, who had 10 points, hit a fadeaway jumper to break a 40-all tie with 11:21 remaining.
Tyler Johnson scored 24 points, while Marvelle Harris added 18 and Cezar Guerrero 13 for Fresno State (13-14, 6-8).
The Associated Press contributed to this report.