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A press conference to announce the hiring will start at 12:05 p.m. ET.
Gillick will replace Ed Wade, fired after failing to get the Phillies into the playoffs during eight years on the job.
A special consultant in the Mariners' front office the past two seasons, Gillick led Toronto to consecutive World Series titles in 1992-93. He was also a general manager with Baltimore and Seattle.
Philadelphia went 88-74 this season and finished one game behind NL wild-card winner Houston. It was the Phillies' third consecutive winning season and fourth in five years, but they missed the playoffs for the 12th straight year and 21st time in 22 seasons.
Gillick won five AL East titles in Toronto and led the Orioles to the AL championship series in 1996 and '97. He also took the Mariners to the ALCS in 2000 and 2001. Seattle tied a major-league record with 116 wins in 2001, and the Mariners' 393 victories during Gillick's four seasons were the most in baseball.
Information from The Associated Press was used in this report.