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Colón developed the blister on the right middle finger of his pitching hand, after throwing six innings in which he allowed four hits and no runs. Cuba went on to win the game 3-1, advancing to the WBC championship game.
"Colón had to leave the game in the sixth inning because of a blister in the middle finger of his right hand," Dominican manager Manny Acta told ESPNdeportes.com. "Thank goodness the blister didn't pop, so we think Colón will be able to pitch in his next outing in five days with the Los Angeles Angels."
Last year's American League Cy Young winner made three starts at the WBC and only allowed one run in 14 innings.
On Saturday, Colón threw 70 pitches -- 25 under the permitted pitch count for the final round -- and 44 of them were strikes.
"He told me he wanted to keep pitching, but he had 10 left for the quota we had for him, so I decided to go to the bullpen," said Acta. "Bartolo did a great job for us in this tournament, and we certainly cannot complain."
Outfielder Moises Alou summed it up best. "One of the things we most feel sorry about in the loss against Cuba was that Colón pitched magnificently, and we didn't support him."
Enrique Rojas is a reporter and columnist for ESPNdeportes.com and ESPN.com.