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Pole-winner Jeff Gordon finished second and teammate Jimmie Johnson was third.
Kenseth also won the Stater Bros. 300 Busch race on Saturday.
With seven laps to go, the race was red-flagged for more than 15 minutes after David Reutimann crashed in Turn 4.
Daytona 500 winner Kevin Harvick was second when the red flag dropped, but realized he had a flat left front tire before the restart with four laps to go.
Brian Vickers, who failed to qualify for the Daytona 500 last week, gave Toyota its best finish with a 10th-place showing in the No. 83 Camry.
Terry Blount covers motorsports for ESPN.com. He can be reached at firstname.lastname@example.org.