Bob Bryan won his sixth Grand Slam mixed doubles title, while partner Liezel Huber won her first.
The title is Bryan's second consecutive in mixed doubles at the French Open and his sixth Grand Slam mixed doubles title overall -- each with a different partner.
"It's gotten better and better each time," he said.
Bryan has also won seven men's doubles major championships with twin brother Mike. They lost in the semifinals at Roland Garros earlier Thursday to Wesley Moodie of South Africa and Dick Norman of Belgium.
"This was a way for me to feel good, you know, to leave here with a win, leave here with a trophy, big title and a Grand Slam," Bryan said.
For Huber, it's her first mixed doubles Grand Slam title. She has won four women's doubles major championships.
"I'm so grateful for playing with Bob," she said. "I truly think we wouldn't have won this title without him."