Schaub appeared to hurt his ankle when he get tangled up at the line on a touchdown run by Steve Slaton with about four minutes left in the first half Monday night.
"I just felt a little something in my ankle and it kind of progressively got a little sore," Schaub said. "I was able to stay in there and just came in at the half and figured it was best to just get some treatment on it and proceed that way."
He got his ankle taped and returned for the last series of the second quarter, where he completed two passes before Houston kicked a field goal. Schaub was replaced by Dan Orlovsky to start the third quarter while the rest of Houston's starters remained in the game.
Schaub was 10-of-14 for 108 yards with one interception. He's missed five games in each of the last two seasons with injuries. He said he expects to play Friday.