Lee sprained his left knee during Penn State's Sept. 19 game against Temple and didn't play in last week's loss to Iowa.
Coach Joe Paterno said Thursday on his weekly radio show that he doesn't think Lee will be able to play. Sophomore Nathan Stupar will most likely start. He missed most of the Iowa game with an ankle injury.
Paterno says the Nittany Lions (3-1, 0-1 Big Ten) will also be without freshman wide receiver and kick returner Devon Smith, who suffered a concussion in last week's game and won't make the trip. Wide receiver Chaz Powell, who also returns kickoffs, has been ill this week.